As you progress through each dungeon, random item drops will be key in helping you infiltrate the Abyss and these passive effects can stack between every item. With no limit to how many can apply; a wide variety of combinations will make each run unique.
With each run, you will be able to unlock new rooms, items, bosses, special rules and even new endings! This means each dungeon is unique and expandable, being tailored to your own specific playstyle.